Construction and comprehensive analysis of the competing endogenous RNA network in endometrial adenocarcinoma.

ABSTRACT:

Background

Endometrial carcinoma (EC) is one of the most common gynecological malignant tumors. In this study, we constructed gene co-expression networks to identify key modules and hub genes involved in the pathogenesis of EC.

Results

The MEturquoise module was found to be significantly related to hypertension and the MEbrown module was significantly related to the history of other malignancies. Functional enrichment analysis showed that the MEturquoise module was associated with the GO biological process terms of transcription from RNA polymerase II promoter, positive regulation of male gonad development, endocardial cushion development, and endothelial cell differentiation. The MEbrown module was associated with GO terms DNA binding, epithelial-to-mesenchymal transition,

SUBMITTER: Feng C 

PROVIDER: S-EPMC8818217 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature