Weighted composite time to event endpoints with recurrent events: comparison of three analytical approaches.

ABSTRACT:

Background

In clinical trials the study interest often lies in the comparison of a treatment to a control regarding a time to event endpoint. A composite endpoint allows to consider several time to event endpoints at once. Usually, only the time to the first occurring event for a patient is thereby analyzed. However, an individual may experience more than one non-fatal event. Including all observed events in the analysis can increase the power and provides a more complete picture of the disease. Thus, analytical methods for recurrent events are required. A challenge is that the different event types belonging to the composite often are of different clinical relevance. In this case, weighting the event types according to their clinical relevance is an option. Different weight-based

SUBMITTER: Ozga AK 

PROVIDER: S-EPMC8818231 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature