Myocarditis following mRNA Covid-19 vaccination: A pooled analysis.

ABSTRACT:

Background

Post-marketing surveillance studies have raised concerns of increased myocarditis rates following coronavirus disease-19 (Covid-19) mRNA vaccines. The present study aims to accumulate the published mRNA Covid-19 vaccine-associated myocarditis cases, describe their clinical characteristics and determine the factors predisposing to critical illness.

Methods

Medline, Scopus, Web of Science, CENTRAL and Google Scholar were systematically searched from inception. Studies reporting adult myocarditis cases following BNT162b2 or mRNA-1273 vaccination were included. Individual participant data coming from case reports/series were pooled. Proportional random-effects meta-analysis was conducted by combining the pooled cohort and observational studies with aggregated data.

SUBMITTER: Bellos I 

PROVIDER: S-EPMC8818354 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature