Immunometabolic signatures predict recovery from thyrotoxic myopathy in patients with Graves' disease.

ABSTRACT:

Background

Thyroid hormone excess induces protein energy wasting, which in turn promotes muscle weakness and bone loss in patients with Graves' disease. Although most studies have confirmed a relationship between thyrotoxicosis and muscle dysfunction, few have measured changes in plasma metabolites and immune cells during the development and recovery from thyrotoxic myopathy. The aim of this study was to identify specific plasma metabolites and T-cell subsets that predict thyrotoxic myopathy recovery in patients with Graves' disease.

Methods

One hundred patients (mean age, 40.0 ± 14.2 years; 67.0% female), with newly diagnosed or relapsed Graves' disease were enrolled at the start of methimazole treatment. Handgrip strength and Five Times Sit to Stand Test performance time w

SUBMITTER: Setoyama D 

PROVIDER: S-EPMC8818593 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature