Myosteatosis as an independent risk factor for mortality after kidney allograft transplantation: a retrospective cohort study.

ABSTRACT:

Background

Patients with end-stage renal disease may display both a loss of skeletal muscle mass and an increase in muscle fat deposits. We aimed to analyse the impact of low skeletal muscle mass index (SMI, surrogate marker of sarcopenia) and low muscle density (MD, surrogate marker of myosteatosis) on patient survival after kidney transplantation (KT).

Methods

In a retrospective cohort of 200 kidney transplant recipients (KTr), we measured on an unenhanced cross-sectional computed tomography scan taken at the level of the third lumbar vertebra within the previous year or at the time of KT, both SMI (muscle cross-sectional area normalized for height² , reported in cm² /m² ) and MD (mean attenuation of muscle cross-sectional area, expressed i

SUBMITTER: Morel A 

PROVIDER: S-EPMC8818595 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature