Muscle-specific functional deficits and lifelong fibrosis in response to paediatric radiotherapy and tumour elimination.

ABSTRACT:

Background

As paediatric cancer survivors are living into adulthood, they suffer from the age-related, accelerated decline of functional skeletal muscle tissue, termed sarcopenia. With ionizing radiation (radiotherapy) at the core of paediatric cancer therapies, its direct and indirect effects can have lifelong negative impacts on paediatric growth and maintenance of skeletal muscle. Utilizing our recently developed preclinical rhabdomyosarcoma mouse model, we investigated the late effects of paediatric radiation treatment on skeletal muscles from late adolescent (8 weeks old) and middle-aged (16 months old) mice.

Methods

Paediatric C57BL/6J male mice (3 weeks old) were injected with rhabdomyosarcoma cells into their right hindlimbs, and then fractionated irradiation (3 × 8.

SUBMITTER: Kallenbach JG 

PROVIDER: S-EPMC8818600 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature