Identification of traumatic acid as a potential plasma biomarker for sarcopenia using a metabolomics-based approach.

ABSTRACT:

Background

The pathogenesis of sarcopenia is complex and has not been well explored. Identifying biomarkers is a promising strategy for exploring the mechanism of sarcopenia. This study aimed to identify potential biomarkers of sarcopenia through a metabolomic analysis of plasma metabolites in elderly subjects (≥65 years of age) vs. younger adults (<65 years of age).

Methods

Of the 168 candidates in the Comprehensive Geriatric Assessment and Frailty Study of Elderly Outpatients, 24 elderly subjects (≥65 years of age) with sarcopenia were age and sex matched with 24 elderly subjects without sarcopenia. In addition, 24 younger adults were recruited for comparison. Muscle strength, gait speed, and metabolic and inflammatory parameters, including plasma tumour necrosis factor-α,

SUBMITTER: Tsai JS 

PROVIDER: S-EPMC8818620 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature