Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice.

ABSTRACT:

Background

Chronic renal failure induces bone mineral disorders and sarcopenia. Skeletal muscle affects other tissues, including bone, by releasing myokines. However, the effects of chronic renal failure on the interactions between muscle and bone remain unclear.

Methods

We investigated the effects of renal failure on bone, muscle, and myokines linking muscle to bone using a mouse 5/6 nephrectomy (Nx) model. Muscle mass and bone mineral density (BMD) were analysed by quantitative computed tomography 8 weeks after Nx.

Results

Nephrectomy significantly reduced muscle mass in the whole body (12.1% reduction, P < 0.05), grip strength (10.1% reduction, P < 0.05), and cortical BMD at the femurs of mice (9.5% reduction, P < 0.01) 8 weeks after surgery, but did not affect tra

SUBMITTER: Kawao N 

PROVIDER: S-EPMC8818650 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature