Effects of AST-120 on muscle health and quality of life in chronic kidney disease patients: results of RECOVERY study.

ABSTRACT:

Background

The prevalence of sarcopenia is increased with declining renal function. Elevated serum indoxyl sulfate levels are associated with poor skeletal muscle conditions. We aimed to determine the effects of AST-120, the oral adsorbent of indoxyl sulfate, on sarcopenia and sarcopenia-associated factors in chronic kidney disease patients.

Methods

This was a 48 week, randomized controlled, parallel group, open-label, multicentre trial (n = 150). The participants were randomly assigned in a 1:1 ratio to the control (CON) and AST-120 (Renamezin®, REN) groups. Outcome measurements were performed at baseline and every 24 weeks for 48 weeks. The primary outcome was gait speed difference ≥0.1 m/s between the two groups, and secondary outcomes included hand grip strength, muscle

SUBMITTER: Cha RH 

PROVIDER: S-EPMC8818653 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature