Ovarian cancer ascites induces skeletal muscle wasting in vitro and reflects sarcopenia in patients.

ABSTRACT:

Background

Cachexia-associated skeletal muscle wasting or 'sarcopenia' is highly prevalent in ovarian cancer and contributes to poor outcome. Drivers of cachexia-associated sarcopenia in ovarian cancer remain elusive, underscoring the need for novel and better models to identify tumour factors inducing sarcopenia. We aimed to assess whether factors present in ascites of sarcopenic vs. non-sarcopenic ovarian cancer patients differentially affect protein metabolism in skeletal muscle cells and to determine if these effects are correlated to cachexia-related patient characteristics.

Methods

Fifteen patients with an ovarian mass and ascites underwent extensive physical screening focusing on cachexia-related parameters. Based on computed tomography-based body composition imaging,

SUBMITTER: Ubachs J 

PROVIDER: S-EPMC8818657 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature