The metabolic landscape in chronic rotator cuff tear reveals tissue-region-specific signatures.

ABSTRACT:

Background

Degeneration of shoulder muscle tissues often result in tearing, causing pain, disability and loss of independence. Differential muscle involvement patterns have been reported in tears of shoulder muscles, yet the molecules involved in this pathology are poorly understood. The spatial distribution of biomolecules across the affected tissue can be accurately obtained with matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). The goal of this pilot study was to decipher the metabolic landscape across shoulder muscle tissues and to identify signatures of degenerated muscles in chronic conditions.

Methods

Paired biopsies of two rotator cuff muscles, torn infraspinatus and intact teres minor, together with an intact shoulder muscle, the del

SUBMITTER: Olie CS 

PROVIDER: S-EPMC8818701 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature