Comprehensive Landscape of Immune Infiltration and Aberrant Pathway Activation in Ischemic Stroke.

ABSTRACT: Ischemic stroke (IS) is a multifactorial disease caused by the interaction of multiple environmental and genetic risk factors, and it is the most common cause of disability. The immune microenvironment and inflammatory response participate in the whole process of IS occurrence and development. Therefore, the rational use of relevant markers or characteristic pathways in the immune microenvironment will become one of the important therapeutic strategies for the treatment of IS. We collected peripheral blood samples from 10 patients diagnosed with IS at the First Affiliated Hospital of Gannan Medical University and First Affiliated Hospital, Jinan" University, and from 10 normal people. The GSE16561 dataset was downloaded from the Gene Expression Omnibus (GEO) database. xCell, gene set enric

SUBMITTER: Liu R 

PROVIDER: S-EPMC8818702 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature