Serum Calcification Propensity and Calcification of the Abdominal Aorta in Patients With Primary Aldosteronism.

ABSTRACT: Patients with primary aldosteronism (PA) are more susceptible to cardiovascular disease and mortality than patients with primary hypertension. This is mostly attributed to excess production of aldosterone and its effects on the development of vascular injury. A novel functional test (T₅₀) measures serum calcification propensity. Lower T₅₀-values predict higher cardiovascular risk. We investigated serum calcification propensity and vascular calcification in PA and resistant hypertension (RH). T₅₀ measurement was performed in patients with PA (n = 66) and RH (n = 28) at baseline and after 403 (279-640) and 389 (277-527) days of treatment. No significant differences in T₅₀-values were observed between the groups (371 ± 65 and 382 ± 44

SUBMITTER: Kantauskaite M 

PROVIDER: S-EPMC8818752 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature