Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease.

ABSTRACT: Animal models of disease are valuable resources for investigating pathogenic mechanisms and potential therapeutic interventions. However, for complex disorders such as Alzheimer's disease (AD), the generation and availability of innumerous distinct animal models present unique challenges to AD researchers and hinder the success of useful therapies. Here, we conducted an in-depth analysis of the 3xTg-AD mouse model of AD across its lifespan to better inform the field of the various pathologies that appear at specific ages, and comment on drift that has occurred in the development of pathology in this line since its development 20 years ago. This modern characterization of the 3xTg-AD model includes an assessment of impairments in long-term potentiation followed by quantification of amyloid

SUBMITTER: Javonillo DI 

PROVIDER: S-EPMC8818877 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature