Hexamerin-2 Protein of Locust as a Novel Allergen in Occupational Allergy.

ABSTRACT:

Background

Occupational exposure to locusts induces a high prevalence of allergic sensitization. However, knowledge on occupational locust allergens remains unclear.

Objective

This study aimed to identify the allergens from locusts causing occupational allergies.

Methods

We conducted a survey of 57 persons exposed to locusts using questionnaires and immunological tests for occupational allergies in long-term locust laboratories. The major allergen was identified by immunoblotting and analysed by mass spectrometry. The allergenicity of the allergen was assessed by sIgE detection, immunoblotting and ELISA inhibition assays.

Results

The survey indicated that the frequency of locust occupational allergies was 40.4% among subjects exposed to locust. The symptoms in

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8818979 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature