Antigen Discovery in Circulating Extracellular Vesicles From Plasmodium vivax Patients.

ABSTRACT: Plasmodium vivax is the most widely distributed human malaria parasite with 7 million annual clinical cases and 2.5 billion people living under risk of infection. There is an urgent need to discover new antigens for vaccination as only two vaccine candidates are currently in clinical trials. Extracellular vesicles (EVs) are small membrane-bound vesicles involved in intercellular communication and initially described in reticulocytes, the host cell of P. vivax, as a selective disposal mechanism of the transferrin receptor (CD71) in the maturation of reticulocytes to erythrocytes. We have recently reported the proteomics identification of P. vivax proteins associated to circulating EVs in P. vivax patients using size exclusion chromatography followed by mass spect

SUBMITTER: Aparici-Herraiz I 

PROVIDER: S-EPMC8819181 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature