Association between depression and sleep apnoea: a Mendelian randomisation study.

ABSTRACT:

Background

Studies have reported a close relationship between depression and sleep apnoea, yet it is unknown whether these are causally related. Thus, we aimed to determine whether depression is associated with the aetiology of sleep apnoea.

Methods

We used publicly available genetic summary data from two large consortia: the Psychiatric Genomics Consortium, with data from 36 single-nucleotide polymorphisms (SNPs) closely associated with major depressive disorder (MDD), and the UK Biobank, including 456 736 patients with sleep apnoea and 766 964 controls. For Mendelian randomisation (MR) analysis, we used the inverse-variance weighted method, weighted median method, MR-Egger regression, MR pleiotropy residual sum and outlier test to retrieve summary data. Analyses were perfo

SUBMITTER: Chen G 

PROVIDER: S-EPMC8819249 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature