Human Foveal Cone and RPE Cell Topographies and Their Correspondence With Foveal Shape.

ABSTRACT:

Purpose

To characterize the association between foveal shape and cone and retinal pigment epithelium (RPE) cell topographies in healthy humans.

Methods

Multimodal adaptive scanning light ophthalmoscopy and optical coherence tomography (OCT) were used to acquire images of foveal cones, RPE cells, and retinal layers in eyes of 23 healthy participants with normal foveas. Distributions of cone and RPE cell densities were fitted with nonlinear mixed-effects models. A linear mixed-effects model was used to examine the relationship between cone and RPE inter-cell distances and foveal shape as obtained from the OCT scans of retinal thickness.

Results

The best-fit model to the cone densities was a power function with a nasal-temporal asymmetry. There was a significant linear r

SUBMITTER: Baraas RC 

PROVIDER: S-EPMC8819292 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature