IL-2 complex recovers steroid-induced inhibition in immunochemotherapy for head and neck cancer.

ABSTRACT:

Background

A combination therapy with immune checkpoint inhibitors (ICIs) and platinum-based chemotherapy has become the first-line treatment for recurrent or metastatic head and neck squamous carcinoma (HNSCC). Although steroids are often used as anti-emetic medications during chemotherapy, their adverse effects on immune-combined chemotherapy are unclear in HNSCC.

Methods

The effects of dexamethasone on tumor growth and immune cell population were evaluated in a mouse HNSCC model treated with PD-1 blockade combined with cisplatin. The effect of various doses of dexamethasone on cell proliferation, survival, surface markers, IFN-γ production, and antitumor effects in antigen-specific T cells was examined in vitro. The recovery of T cell dysfunction by IL-2 was assessed in v

SUBMITTER: Kono M 

PROVIDER: S-EPMC8819385 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature