The Immunomodulating Effects of Thalidomide and Dexamethasone in a Murine Cardiac Allograft Transplantation Model.

ABSTRACT:

Purpose

The immunomodulatory effects of thalidomide (TM) and dexamethasone (DX) on immune cells and their co-stimulatory, co-inhibitory molecules in vitro and in vivo have been previously reported. The current study investigated the effects of TM and the combinatorial treatment with DX on immune cells using a murine cardiac allograft transplantation model.

Materials and methods

Intraabdominal transplant of cardiac allografts from BALB/c (H-2^d) donors to C57BL/6 (H-2^b) recipients was performed. After transplantation, mice were injected daily with TM or DX or a combination of both TM and DX (TM/DX) by intraperitoneal route until the time of graft loss. CD4⁺ T cell subsets and CD11c⁺ cells in the peripheral blood mononuclear cells and

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC8819408 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature