Redetermination of the structure of 2-amino-8-thia-1,5-di-aza-spiro-[4.5]dec-1-en-5-ium chloride monohydrate.

ABSTRACT: The reaction of β-(thio-morpholin-1-yl)propio-amidoxime with tosyl chloride in CHCl₃ in the presence of DIPEA when heated at 343 K for 8 h afforded the title hydrated salt, C₇H₁₄N₃S⁺·Cl^-·H₂O, in 84% yield. This course of the tosyl-ation reaction differs from the result of tosyl-ation obtained for this substrate at room temperature, when only 2-amino-8-thia-1,5-di-aza-spiro-[4.5]dec-1-ene-5-ammonium tosyl-ate was isolated in 56% yield. The structure of the reaction product was established by physicochemical methods, spectroscopy, and X-ray diffraction. The single-crystal data demonstrated that the previously reported crystal structure of this compound [Kayukova et al. (2021). Chem. J. Kaz, 74,

SUBMITTER: Kayukova LA 

PROVIDER: S-EPMC8819427 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature