Neonatal multidrug-resistant gram-negative infection: epidemiology, mechanisms of resistance, and management.

ABSTRACT: Infants admitted to the neonatal intensive care unit, particularly those born preterm, are at high risk for infection due to the combination of an immature immune system, prolonged hospitalization, and frequent use of invasive devices. Emerging evidence suggests that multidrug-resistant gram-negative (MDR-GN) infections are increasing in neonatal settings, which directly threatens recent and ongoing advances in contemporary neonatal care. A rising prevalence of antibiotic resistance among common neonatal pathogens compounds the challenge of optimal management of suspected and confirmed neonatal infection. We review the epidemiology of MDR-GN infections in neonates in the United States and internationally, with a focus on extended-spectrum β-lactamase (ESBL)-producing Enterobacterales and c

SUBMITTER: Flannery DD 

PROVIDER: S-EPMC8819496 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature