An exploratory assessment of serum biomarkers of post-cardiac arrest syndrome in children.

ABSTRACT:

Aim

We hypothesized that serum biomarkers of inflammation including chemokine, cytokine, pituitary hormones, and growth factors following cardiac arrest in children would independently associate with 6-month neurologic outcome.

Methods

In this prospective observational single center study of children with in-hospital and out-of-hospital cardiac arrest surviving to intensive care unit admission, serum was obtained twice per 24 h period between 0 h and 96 h and once at approximately 196 h post-cardiac arrest. Inflammatory mediators, hormones, and growth factors were analyzed by Luminex Multiplex Bead Immunoassay. We recorded demographics, resuscitation characteristics, and Pediatric Cerebral Performance Category (PCPC) at 6 months. We analyzed the association and area under th

SUBMITTER: Kernan KF 

PROVIDER: S-EPMC8819629 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature