The effect of valproic acid on SLC5A8 expression in gonad-intact and gonadectomized rat thymocytes.

ABSTRACT:

Background

Valproic acid (VPA) pharmacological mechanisms are related to the anti-inflammatory and anti-viral effects. VPA is a histone deacetylases inhibitor and serves a role in its immunomodulatory impacts. VPA has complex effects on immune cell's mitochondrial metabolism. The SLC5A8 transporter of short fatty acids has an active role in regulating mitochondrial metabolism. The study aimed to investigate whether SLC5A8 expresses the sex-related difference and how SLC5A8 expression depends on gonadal hormones, VPA treatment, and NKCC1 expression in rat thymocytes.

Methods

Control groups and VPA-treated gonad-intact and gonadectomized Wistar male and female rats were investigated (n = 6 in a group). The VPA 300 mg/kg/day in drinking water was given for 4 weeks. The S

SUBMITTER: Jukneviciene M 

PROVIDER: S-EPMC8819739 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature