Structural evidence of the oxidation of iodide ion into hyper-reactive hypoiodite ion by mammalian heme lactoperoxidase.

ABSTRACT: Lactoperoxidase (1.11.1.7, LPO) is a mammalian heme peroxidase found in the extracellular fluids of mammals including plasma, saliva, airway epithelial lining fluids, nasal lining fluid, milk, tears, gastric juices, and intestinal mucosa. To perform its innate immune action against invading microbes, LPO utilizes hydrogen peroxide (H₂ O₂ ) to convert thiocyanate (SCN^- ) and iodide (I^- ) ions into the oxidizing compounds hypothiocyanite (OSCN^- ) and hypoiodite (IO^- ). Previously determined structures of the complexes of LPO with SCN^- , OSCN^- , and I^- show that SCN^- and I^- occupy appropriate positions in the distal heme cavity as substrates while OSCN^- binds in

SUBMITTER: Singh PK 

PROVIDER: S-EPMC8819834 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature