Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta.

ABSTRACT:

Background

The maternal microbiota affects the development of the offspring by microbial metabolites translocating to the fetus. To reveal the spectrum of these molecular mediators of the earliest host-microbe interactions, we compared placenta, fetal intestine and brain from germ-free (GF) and specific pathogen free (SPF) mouse dams by non-targeted metabolic profiling.

Results

One hundred one annotated metabolites and altogether 3680 molecular features were present in significantly different amounts in the placenta and/or fetal organs of GF and SPF mice. More than half of these were more abundant in the SPF organs, suggesting their microbial origin or a metabolic response of the host to the presence of microbes. The clearest separation was observed in the placenta, but most

SUBMITTER: Pessa-Morikawa T 

PROVIDER: S-EPMC8819883 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature