Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy.

ABSTRACT:

Background

Multiple system atrophy (MSA) is a neurodegenerative condition characterized by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and pyramidal features. Although the distribution of synucleinopathy correlates with the predominant clinical features, the burden of pathology does not fully explain observed differences in clinical presentation and rate of disease progression. We hypothesized that the clinical heterogeneity in MSA is a consequence of variability in the seeding activity of α-synuclein both between different patients and between different brain regions.

Methods

The reliable detection of α-synuclein seeding activity derived from MSA using cell-free amplification assays remains challenging. Therefore, we conducted a systematic ev

SUBMITTER: Martinez-Valbuena I 

PROVIDER: S-EPMC8819887 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature