Collagen mineralization with lepidocrocite via Fe(OH)₂ addition.

ABSTRACT: The mineralization of collagen in vitro has been extensively investigated for hydroxyapatite, silica, calcium carbonate and lepidocrocite (γ-FeOOH). Henceforth, it is interesting to investigate whether collagen also could serve as a generic mineralization template for other minerals, like magnetite. To this end, and inspired by the partial oxidation approach, first a ferrous hydroxide (Fe(OH)₂) intermediate is synthesized via the titration of base to a solution of Fe²⁺. Subsequently, the Fe(OH)₂ is mixed with collagen fibrils and poly(aspartic acid) is added to promote the formation of intrafibrillar crystals. Platelet-shaped lepidocrocite crystals being present throughout the entire thickness of the collagen fibrils can be realized, as was co

SUBMITTER: Oosterlaken BM 

PROVIDER: S-EPMC8819979 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature