Acute Treatment Effects on GFR in Randomized Clinical Trials of Kidney Disease Progression.

ABSTRACT:

Background

Acute changes in GFR can occur after initiation of interventions targeting progression of CKD. These acute changes complicate the interpretation of long-term treatment effects.

Methods

To assess the magnitude and consistency of acute effects in randomized clinical trials and explore factors that might affect them, we performed a meta-analysis of 53 randomized clinical trials for CKD progression, enrolling 56,413 participants with at least one estimated GFR measurement by 6 months after randomization. We defined acute treatment effects as the mean difference in GFR slope from baseline to 3 months between randomized groups. We performed univariable and multivariable metaregression to assess the effect of intervention type, disease state, baseline GFR, and albuminuri

SUBMITTER: Neuen BL 

PROVIDER: S-EPMC8819983 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature