Paraspinal muscle degeneration and regenerative potential in a Murine model of Lumbar Disc Injury.

ABSTRACT:

Background context

The association between low back pain and lumbar disc degeneration is not fully characterized. One potentially overlooked factor of this process is the lumbar multifidus, which plays a role in segmental stabilization and locomotion. Previous reports have shown multifidus degeneration to be associated with disc degeneration. The goal of this study was to develop a mouse model of advanced lumbar disc degeneration to recapitulate the pathology of the human multifidus in patients with lumbar disc degeneration and low back pain.

Methods

C57BL/6 mice underwent a left anterolateral approach to the lumbar spine and disc puncture with a micro scalpel at L5/6 and L6/S1. Mice underwent behavioral analysis and functional gait testing. A subset of mice underwent 14T T2

SUBMITTER: Davies MR 

PROVIDER: S-EPMC8820077 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature