The Impact of IFNλ4 on the Adaptive Immune Response to SARS-CoV-2 Infection.

ABSTRACT: Genetic polymorphisms at the IFNL4 loci are known to influence the clinical outcome of several different infectious diseases. Best described is the association between the IFNL4 genotype and hepatitis C virus clearance. However, an influence of the IFNL4 genotype on the adaptive immune system was suggested by several studies but never investigated in humans. In this cross-sectional study, we have genotyped 201 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive participants for 3 IFNL4 polymorphisms (rs368234815, rs12979860, and rs117648444) and stratified them according to the IFNλ4 activity. Based on this stratification, we investigated the association between the IFNL4 genotype and the antibody as well as the CD8⁺ T cell re

SUBMITTER: Mohlenberg M 

PROVIDER: S-EPMC8820097 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature