Dataset Information

Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females.

ABSTRACT: We assessed sex differences in amyloid- and tau-PET retention in 119 amyloid positive patients with mild cognitive impairment or Alzheimer's disease (AD) dementia. Patients underwent 3T-MRI, ¹¹C-PIB amyloid-PET and ¹⁸F-Flortaucipir tau-PET. Linear ordinary least squares regression models tested sex differences in Flortaucipir-PET SUVR in a summary temporal region of interest as well as global PIB-PET. No sex differences were observed in demographics, Clinical Dementia Rating Sum of Boxes (CDR-SoB), Mini-Mental State Exam (MMSE), raw episodic memory scores, or cortical thickness. Females had higher global PIB SUVR (η_p²=.043, p=.025) and temporal Flortaucipir SUVR (η_p²=.070, p=.004), adjusting for age and CDR-SoB. Sex differences in temporal Flortaucipir-PET remained significant when controlling additionally for PIB SUVR and APOE4 status (η_p²=.055, p=.013), or when using partial volume-corrected data. No sex differences were present in areas of known Flortaucipir off-target binding. Overall, females demonstrated greater AD regional tau-PET burden than males despite clinical comparability. Further characterization of sex differences will provide insight into AD pathogenesis and support development of personalized therapeutic strategies.

SUBMITTER: Edwards L

PROVIDER: S-EPMC8820163 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females.

Edwards Lauren L La Joie Renaud R Iaccarino Leonardo L Strom Amelia A Baker Suzanne L SL Casaletto Kaitlin B KB Cobigo Yann Y Grant Harli H Kim Minseon M Kramer Joel H JH Mellinger Taylor J TJ Pham Julie J Possin Katherine L KL Rosen Howard J HJ Soleimani-Meigooni David N DN Wolf Amy A Miller Bruce L BL Rabinovici Gil D GD

Neurobiology of aging 20210422

We assessed sex differences in amyloid- and tau-PET retention in 119 amyloid positive patients with mild cognitive impairment or Alzheimer's disease (AD) dementia. Patients underwent 3T-MRI, <sup>11</sup>C-PIB amyloid-PET and <sup>18</sup>F-Flortaucipir tau-PET. Linear ordinary least squares regression models tested sex differences in Flortaucipir-PET SUVR in a summary temporal region of interest as well as global PIB-PET. No sex differences were observed in demographics, Clinical Dementia Ratin ...[more]

PMID: 34049062

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Dataset Information

Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females.

Publications

Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females.

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