Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females.

ABSTRACT: We assessed sex differences in amyloid- and tau-PET retention in 119 amyloid positive patients with mild cognitive impairment or Alzheimer's disease (AD) dementia. Patients underwent 3T-MRI, ¹¹C-PIB amyloid-PET and ¹⁸F-Flortaucipir tau-PET. Linear ordinary least squares regression models tested sex differences in Flortaucipir-PET SUVR in a summary temporal region of interest as well as global PIB-PET. No sex differences were observed in demographics, Clinical Dementia Rating Sum of Boxes (CDR-SoB), Mini-Mental State Exam (MMSE), raw episodic memory scores, or cortical thickness. Females had higher global PIB SUVR (η_p²=.043, p=.025) and temporal Flortaucipir SUVR (η_p²=.070, p=.004), adjusting for age and CDR-SoB. Sex differences in temporal Florta

SUBMITTER: Edwards L 

PROVIDER: S-EPMC8820163 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature