Macrophage-Based Combination Therapies as a New Strategy for Cancer Immunotherapy.

ABSTRACT:

Background

Cells of the immune system can inhibit tumor growth and progression; however, immune cells can also promote tumor cell growth, survival, and angiogenesis as a result of the immunosuppressive microenvironments. In the last decade, a growing number of new therapeutic strategies focused on reversing the immunosuppressive status of tumor microenvironments (TMEs), to reprogram the TME to be normal, and to further activate the antitumor functions of immune cells. Most of the "hot tumors" are encompassed with M2 macrophages promoting tumor growth, and the accumulation of M2 macrophages into tumor islets leads to poor prognosis in a wide variety of tumors.

Summary

Therefore, how to uncover more immunosuppressive signals and to reverse the M2 tumor-associated macrophages (

SUBMITTER: Tian L 

PROVIDER: S-EPMC8820174 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature