Timing of sinusitis and other respiratory tract diseases and risk of rheumatoid arthritis.

ABSTRACT:

Objective

To investigate the association between timing of respiratory tract diseases and risk of rheumatoid arthritis (RA).

Methods

This case-control study using the Mass General Brigham Biobank matched incident RA cases, confirmed by ACR/EULAR criteria, with at least seven years preceding electronic health record (EHR) data to three controls on age, sex, and EHR history from RA diagnosis (index date). We ascertained timing (>0-5 years/>5-10 years/>10 years) of the first documented respiratory tract disease prior to index date using diagnosis codes. We estimated odds ratios (OR) with 95% confidence intervals (CI) for RA for each respiratory exposure using logistic regression models, adjusting for potential confounders. We also conducted a stratified analysis by serostatus a

SUBMITTER: Kronzer VL 

PROVIDER: S-EPMC8820230 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature