Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer.

ABSTRACT:

Objective

Mebendazole and other anti-parasitic drugs are being used off-prescription based on social media and unofficial accounts of their anti-cancer activity. The purpose of this study was to conduct a controlled evaluation of mebendazole's therapeutic efficacy in cell culture and in vivo models of ovarian cancer. The majority of ovarian cancers harbor p53 null or missense mutations, therefore the effects of p53 mutations and a mutant p53 reactivator, PRIMA-1^MET (APR246) on mebendazole activity were evaluated.

Methods

Mebendazole was evaluated in cisplatin-resistant high grade serous stage 3C ovarian cancer patient derived xenograft (PDX) models: PDX-0003 (p53 null) and PDX-0030 (p53 positive), and on ovarian cancer cell lines: MES-OV (p53 R282W), ES2 (p53 S241

SUBMITTER: Elayapillai S 

PROVIDER: S-EPMC8820236 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature