Excessive Oxygen Supplementation in the First Day of Mechanical Ventilation Is Associated With Multiple Organ Dysfunction and Death in Critically Ill Children.

ABSTRACT:

Objectives

To determine if greater cumulative exposure to oxygen despite adequate oxygenation over the first 24 hours of mechanical ventilation is associated with multiple organ dysfunction syndrome at 7 days and inhospital mortality in critically ill children.

Design

Retrospective, observational cohort study.

Setting

Two urban, academic PICUs.

Patients

Patients less than 18 years old who required mechanical ventilation within 3 days of admission between 2010 and 2018 (Lurie Children's Hospital) or 2010 and 2016 (Comer Children's Hospital).

Interventions

None.

Measurements and main results

There were 5,406 mechanically ventilated patients, of which 960 (17.8%) had multiple organ dysfunction syndrome on day 7 of admission and 319 died (5.9%) during

SUBMITTER: Balcarcel DR 

PROVIDER: S-EPMC8820279 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature