Poor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI Scans.

ABSTRACT:

Background

We aimed to assess the correlation of lesion location and clinical outcome in patients with large hemispheric infarction (LHI).

Methods

We analyzed admission MRI data from the GAMES-RP trial, which enrolled patients with anterior circulation infarct volumes of 82-300 cm³ within 10 hours of onset. Infarct lesions were segmented and co-registered onto MNI-152 brain space. Voxel-wise general linear models were applied to assess location-outcome correlations after correction for infarct volume as a co-variate.

Results

We included 83 patients with known 3-month modified Rankin scale (mRS). In voxel-wise analysis, there was significant correlation between admission infarct lesions involving the anterior cerebral artery (ACA) territory and its middle ce

SUBMITTER: Payabvash S 

PROVIDER: S-EPMC8820410 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature