Pregnancy in Women with Atypical Hemolytic Uremic Syndrome.

ABSTRACT:

Background

Pregnancy outcomes in patients with atypical hemolytic uremic syndrome (aHUS) are not well-documented. Here, we present characteristics of and outcomes for patients with aHUS who became pregnant while enrolled in the Global aHUS Registry.

Methods

The observational Global aHUS Registry (NCT01522183), initiated in April 2012, collects demographics, disease history, treatment, and outcomes data for patients with aHUS, regardless of treatment approach. This descriptive analysis includes patients from the Registry with evaluable pregnancy data supplemented with pharmacovigilance information; the number of pregnancies, outcomes, and exposure to eculizumab were evaluated.

Results

As of April 1, 2019, 44 pregnancies were recorded in 41 patients, with 24 pregnancies

SUBMITTER: Rondeau E 

PROVIDER: S-EPMC8820436 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature