Microstructural Characterization of Resistance Artery Remodelling in Diabetes Mellitus.

ABSTRACT:

Introduction

Microvascular remodelling is a symptom of cardiovascular disease. Despite the mechanical environment being recognized as a major contributor to the remodelling process, it is currently only understood in a rudimentary way.

Objective

A morphological and mechanical evaluation of the resistance vasculature in health and diabetes mellitus.

Methods

The cells and extracellular matrix of human subcutaneous resistance arteries from abdominal fat biopsies were imaged using two-photon fluorescence and second harmonic generation at varying transmural pressure. The results informed a two-layer mechanical model.

Results

Diabetic resistance arteries reduced in wall area as pressure was increased. This was attributed to the presence of thick, straight collagen fi

SUBMITTER: Bell JS 

PROVIDER: S-EPMC8820441 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature