Transient receptor potential ankyrin 1 channel: An evolutionarily tuned thermosensor.

ABSTRACT: The discovery of the role of the transient receptor potential ankyrin 1 (TRPA1) channel as a polymodal detector of cold and pain-producing stimuli almost two decades ago catalyzed the consequent identification of various vertebrate and invertebrate orthologues. In different species, the role of TRPA1 has been implicated in numerous physiological functions, indicating that the molecular structure of the channel exhibits evolutionary flexibility. Until very recently, information about the critical elements of the temperature-sensing molecular machinery of thermosensitive ion channels such as TRPA1 had lagged far behind information obtained from mutational and functional analysis. Current developments in single-particle cryo-electron microscopy are revealing precisely how the thermosensitive

SUBMITTER: Sinica V 

PROVIDER: S-EPMC8820563 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature