Neuroinflammation, Early-Life Adversity, and Brain Development.

ABSTRACT:

Abstract

The overarching objective is to review how early exposure to adversity interacts with inflammation to alter brain maturation. Both adversity and inflammation are significant risk factors for psychopathology. Literature relevant to the effects of adversity in children and adolescents on brain development is reviewed. These studies are supported by research in animals exposed to species-relevant stressors during development. While it is known that exposure to adversity at any age increases inflammation, the effects of inflammation are exacerbated at developmental stages when the immature brain is uniquely sensitive to experiences. Microglia play a vital role in this process, as they scavenge cellular debris and prune synapses to optimize performance. In essence, microglia mo

SUBMITTER: Andersen SL 

PROVIDER: S-EPMC8820591 | biostudies-literature | 2022 Jan-Feb 01

REPOSITORIES: biostudies-literature