Astrocyte in prion disease: a double-edged sword.

ABSTRACT: Prion diseases are infectious protein misfolding disorders of the central nervous system that result from misfolding of the cellular prion protein (PrP^C) into the pathologic isoform PrP^Sc. Pathologic hallmarks of prion disease are depositions of pathological prion protein PrP^Sc, neuronal loss, spongiform degeneration and astrogliosis in the brain. Prion diseases affect human and animals, there is no effective therapy, and they invariably remain fatal. For a long time, neuronal loss was considered the sole reason for neurodegeneration in prion pathogenesis, and the contribution of non-neuronal cells like microglia and astrocytes was considered less important. Recent evidence suggests that neurodegeneration during prion pathogenesis is a consequence of a comp

SUBMITTER: Tahir W 

PROVIDER: S-EPMC8820723 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature