Associations between the von Willebrand Factor-ADAMTS13 Axis, Complement Activation, and COVID-19 Severity and Mortality.

ABSTRACT:

Background

 Endothelial and complement activation were both associated with immunothrombosis, a key determinant of COVID-19 severity, but their interrelation has not yet been investigated.

Objectives

 We aimed to determine von Willebrand factor (VWF) antigen (VWF:Ag) concentration, VWF collagen binding activity (VWF:CBA), a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) activity (ADAMTS13:Ac), and their ratios in hospitalized COVID-19 patients, and to investigate how these parameters and their constellation with complement activation relate to disease severity and in-hospital mortality in COVID-19.

Methods

 Samples of 102 hospitalized patients with polymerase chain reaction-confirmed severe acute respiratory syndrome coronav

SUBMITTER: Sinkovits G 

PROVIDER: S-EPMC8820843 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature