Mechanistic Insights of Qingre Jiedu Recipe Based on Network Pharmacology Approach against Heart Failure.

ABSTRACT: Qingre Jiedu (QJ) recipe exerted significant cardioprotective efficacy against heart failure (HF), which is a growing health concern that continues to endanger patients' lives. To investigate the protective properties and mechanism of the QJ recipe, we established hydrogen peroxide (H₂O₂)-induced H9C2 cells and HF rats. The predicted targets and significant pathways of QJ against HF were collected and screened based on network pharmacology from key ingredients and validated by in vivo and in vitro experiments. The decoction of QJ (0.823 g/kg/day) was intragastrically administered for four weeks. QJ (400 μg/mL) was cultured with H₂O₂ stimulated in the H9C2 cells. A total of 31 effective active compounds were screened in QJ and

SUBMITTER: Li X 

PROVIDER: S-EPMC8820871 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature