A TRP Family Based Signature for Prognosis Prediction in Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Purpose

Head and neck squamous cell carcinoma (HNSCC) is a classical type of head and neck cancers, with heterogeneous clinical outcome. This project is set out to create a robust risk signature based on TRP family genes (TFGs) for prognosis evaluation in HNSCC.

Methods

Based on the HNSCC sample data from the TCGA website, we integrated expression profile of TFGs for 490 HNSCC cases. We explore the interactions among TFGs using STRING tool. The TFGs-based signature (TFBS) was created by Cox relative analyses. In addition, we conducted GSEA to identify the underlying signaling pathways of the specific TFGs in HNSCC. The immune landscape of HNSCC patients was analyzed by CIBERSORT and ssGSEA algorithms.

Results

A total of 6 TFGs (TRPC1, TRPC3, TRPC6, TRPV2, TRPV4, and T

SUBMITTER: Pan F 

PROVIDER: S-EPMC8820906 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature