Long-Term Outcomes of Longitudinal Efficacy Study With Tolvaptan in ADPKD.

ABSTRACT:

Introduction

The effects of long-term and uninterrupted tolvaptan treatment on autosomal dominant polycystic kidney disease (ADPKD) are unclear. Therefore, a more than 3-year continuous treatment study was performed.

Methods

From the Kyorin University cohort, 299 patients were surveyed and 179 patients were indicated for tolvaptan having a total kidney volume (TKV) ≥750 ml, TKV slope ≥5%/yr, and estimated glomerular filtration rate (eGFR) ≥15 ml/min per 1.73 m². Among 179 patients, 118 patients consented to the study.

Results

Retrospective pretreatment and prospective on-treatment periods had a median of 1.8 and 4.0 years, respectively. During the 5 treatment-years, the log₁₀(TKV) slope/yr decreased from the pretreatment period (P < 0.0001

SUBMITTER: Higashihara E 

PROVIDER: S-EPMC8820994 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature