Three-Year Clinical Outcomes of the First South Asian Prospective Longitudinal Observational IgA Nephropathy Cohort.

ABSTRACT:

Introduction

Glomerular Research And Clinical Experiments-IgA Nephropathy in Indians (GRACE-IgANI) is the first prospective South Asian IgA nephropathy (IgAN) cohort with prespecified objectives, protocolized longitudinal follow-up, and extensive biosample collection. The baseline risk scores predicted high risk of kidney disease progression.

Methods

A total of 195 of 201 patients (97%) completed 3-year follow-up in September 2020. All patients received optimized supportive care, and those at high risk of progression were offered systemic corticosteroids.

Results

A total of 76 patients (76 of 193, 39.4%) had rapid progression in 3 years (≥5 ml/min per 1.73 m² decline in estimated glomerular filtration rate [eGFR] per year). A total of 72 patients (72 of 195

SUBMITTER: Alexander S 

PROVIDER: S-EPMC8820995 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature