Predicting Survival in Repaired Tetralogy of Fallot: A Lesion-Specific and Personalized Approach.

ABSTRACT:

Objectives

This study sought to identify patients with repaired tetralogy of Fallot (rTOF) at high risk of death and malignant ventricular arrhythmia (VA).

Background

To date there is no robust risk stratification scheme to predict outcomes in adults with rTOF.

Methods

Consecutive patients were prospectively recruited for late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) to define right and left ventricular (RV, LV) fibrosis in addition to proven risk markers.

Results

The primary endpoint was all-cause mortality. Of the 550 patients (median age 32 years, 56% male), 27 died (mean follow-up 6.4 ± 5.8; total 3,512 years). Mortality was independently predicted by RVLGE extent, presence of LVLGE, RV ejection fraction ≤47%, LV ejection fractio

SUBMITTER: Ghonim S 

PROVIDER: S-EPMC8821017 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature