Reward learning and working memory: Effects of massed versus spaced training and post-learning delay period.

ABSTRACT: Neuroscience research has illuminated the mechanisms supporting learning from reward feedback, demonstrating a critical role for the striatum and midbrain dopamine system. However, in humans, short-term working memory that is dependent on frontal and parietal cortices can also play an important role, particularly in commonly used paradigms in which learning is relatively condensed in time. Given the growing use of reward-based learning tasks in translational studies in computational psychiatry, it is important to understand the extent of the influence of working memory and also how core gradual learning mechanisms can be better isolated. In our experiments, we manipulated the spacing between repetitions along with a post-learning delay preceding a test phase. We found that learning was slo

SUBMITTER: Wimmer GE 

PROVIDER: S-EPMC8821056 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature