CDNF and MANF regulate ER stress in a tissue-specific manner.

ABSTRACT: Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) display cytoprotective effects in animal models of neurodegenerative diseases. These endoplasmic reticulum (ER)-resident proteins belong to the same protein family and function as ER stress regulators. The relationship between CDNF and MANF function, as well as their capability for functional compensation, is unknown. We aimed to investigate these questions by generating mice lacking both CDNF and MANF. Results showed that CDNF-deficient Manf^-/- mice presented the same phenotypes of growth defect and diabetes as Manf^-/- mice. In the muscle, CDNF deficiency resulted in increased activation of unfolded protein response (UPR), which was aggravated when MANF was abl

SUBMITTER: Pakarinen E 

PROVIDER: S-EPMC8821067 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature